The Effect and Mechanism of Rosiglitazone Intervention on Pathology of Diabetic Nephropathy of Type 2 Diabetic Rats

Objective To explore the effect of Rosiglitazone on pathology of Diabetic Nephropath of Type 2 Diabetic Rats and its mechanism.Methods SOD rats with nomal diet(n=10)were selected as control group.35 rats with high-sucrose-high-fat diet were injected with a low dose of STZ(35 mg/kg)to induce diabetic rats model.Then diabetic rats were randomly divided into 2 groups:diabetic group(treated with intervention by Rosiglitazone(3mg/kg,lavage n=10),diabetic group without intervention(n=9),in the 12th weeks after intervention.All rats were sacrificed and then the following information were evaluated such as serum glucose,serum lipid,insulin sensitivity index,mean glomerular area,mean mesangial matrix area,score of mesangial matrix expand were observed by optical microscope.Results In Comparison with control group,All indexes of Rosiglitazone intervention group had no significant difference.All indexes of unintervention diabetic group were significantly high while insulin sensitivity index was decreased.Conclusions Rosiglitazone intervention treatment has protective effects on pathology of diabetic nephropathy.