Protection of rosiglitazone on kidney changes in STZ induced diabetic rats

ObjectiveTo observe the effects of rosiglitazone on kidney damage in streptozotocin induced diabetic rats.MethodsForty male Sprague-Dawley rats were randomized into 3 groups: normal control rats(group C,n=10),diabetic rats(group DC,n=15) and treated diabetic rats(group DR,n=15).The dibetes was induced with streptozotocin(STZ) 60 mg·kg-1 ip;the diabetic rats were treated with axenic rosiglitazone 4 mg·kg-1 in water by mouth qd.Blood glucose,HbA1c,BUN,microalbuminuria and kidney pathological changes were examined 10 weeks after treatment.ResultsThe pathological changes of kidney in group DC included stenosis or occlusion of capillaries,proliferation of mesangial cells and thickening of glomerular basement membrane;all of these changes got improved after treatment in group DR.The levels of urea nitrogen and microalbuminuria were significantly lower in group DR than in group DC,but still higher than in group C(P0.01).ConclusionRosiglitazone can improve or retard the nephropathology in diabetic rats,exerting certain protective effects on the kidney.