2004•Zhonghua shenzangbing zazhiRequires access

Protective effect of rosiglitazone on diabetic rat kidney

Liu Zhang

Abstract

Objective To investigate the mechanism of renal protective effect of rosiglitazone on diabetic rat kidney. Methods Eighteen rats were assigned to normal control(C) group,diabetic rat(DM) group, rosiglitazone(5 mg·kg-1·d-1)treatment(R) group.Immunohistochemistry,RT PCR,Western blot were used to examine the pathological change of kidney and expression of PPARγ、TGF β1 after 8 weeks in the kidney of rats. Results In comparison with normal group, the expression of PPARγand TGF β1 in diabetic rat and treatment groups was markedly increased(P 0 05). In comparison with diabetic rat group,rosiglitazone could significantly decrease the expression of PPARγ、TGF β1(P 0 05). Conclusion Rosiglitazone may play a protective role of the kidney by activating PPARγ,down regulating TGF β1 and alleviating renal injury in diabetic rat.

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Available abstract

Key concepts: Rosiglitazone, Internal medicine, Kidney, Endocrinology, Medicine, Immunohistochemistry, Western blot, Diabetes mellitus