2012•Zhongguo kangfu lilun yu shijianRequires access
Effect of Shuyuningxin Decoction on the Expression of Bcl-2 and Bax in Hippocampus of Chronic Stress Depression Rats
Zhigao Sun
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Abstract
Objective To investigate the effect of Shuyuningxin decoction on the expression of Bcl-2 and Bax in hippocampus of chronic stress depression rats.Methods 60 SD rats were randomly divided into control group,model group,fluoxetine group,high dose of Shuyuningxin decoction group,middle dose of Shuyuningxin decoction group and low dose of Shuyuningxin decoction group.All the groups were given the chronic unpredicted mild stress for 21 d to induce depression models except the control group.Then they were administrated their drugs for 21 d.The level of Bcl-2 and Bax in hippocampus were investigated with immunohistochemistry technique.Results Compared with the control group,the level of Bax increased and Bcl-2 decreased in the model group(P0.05).Compared with model group,the level of Bax decreased and Bcl-2 increased in the middle dose of Shuyuningxin decoction group,high dose of Shuyuningxin decoction group and the fluoxetine group(P0.05).Conclusion The anti-depression effect of Shuyuningxin decoction may be associated with the expression of Bax and Bcl-2.