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Effects of Ning-Shen Wen-Dan decoction to the expression of apoptosis protein Bax,bcl-2 in hippocampus of rats

HE You-shun

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Abstract

Objective: To investigate the Ningshen-Wendan decoction to the expression of neuronal apoptosis gene bax,bcl-2,of the schizophrenia model rat hippocampal.Methods: 40 SD rats were randomly divided into four groups:normal group,model group.Ning Shen-wendan group,chlopromazine group.Each group were administered 1 times / d,21d,after the last day of dosing 1h intraperitoneal injection of saline,normal group 2mg·kg-1,ip the other three groups intraperitoneal injection of apomorphine hydrochloride half water 2mg · kg-1,observed after 15min were decapitated.Results: Compared with model group,the Ningshen-Wendan decoction group,chlorpromazine group bax reduced,bcl-2 increased,bcl-2/bax ratio increased,the difference was statistically significant(P0.01~0.05) Conclusion:Ningsheng-Wendan decoction can inhibit neuronal apoptosis.

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What this paper is about

Objective: To investigate the Ningshen-Wendan decoction to the expression of neuronal apoptosis gene bax,bcl-2,of the schizophrenia model rat hippocampal.Methods: 40 SD rats were randomly divided into four groups:normal group,model group.Ning Shen-wendan group,chlopromazine group.Each group were administered 1 times / d,21d,after the last day of dosing 1h intraperitoneal injection of saline,normal group 2mg·kg-1,ip the other three groups intraperitoneal injection of apomorphine hydrochloride half water 2mg · kg-1,observed after 15min were decapitated.Results: Compared with model group,the Ningshen-Wendan decoction group,chlorpromazine group bax reduced,bcl-2 increased,bcl-2/bax ratio increased,the difference was statistically significant(P0.01~0.05) Conclusion:Ningsheng-Wendan decoction can inhibit neuronal apoptosis.

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Available abstract

Objective: To investigate the Ningshen-Wendan decoction to the expression of neuronal apoptosis gene bax,bcl-2,of the schizophrenia model rat hippocampal.Methods: 40 SD rats were randomly divided into four groups:normal group,model group.Ning Shen-wendan group,chlopromazine group.Each group were administered 1 times / d,21d,after the last day of dosing 1h intraperitoneal injection of saline,normal group 2mg·kg-1,ip the other three groups intraperitoneal injection of apomorphine hydrochloride half water 2mg · kg-1,observed after 15min were decapitated.Results: Compared with model group,the Ningshen-Wendan decoction group,chlorpromazine group bax reduced,bcl-2 increased,bcl-2/bax ratio increased,the difference was statistically significant(P0.01~0.05) Conclusion:Ningsheng-Wendan decoction can inhibit neuronal apoptosis.

Key concepts: Decoction, Intraperitoneal injection, Apoptosis, Saline, Normal group, Medicine, Pharmacology, Hippocampus

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Effects of Ning-Shen Wen-Dan decoction to the expression of apoptosis protein Bax,bcl-2 in hippocampus of rats — Research Paper | ScholarLens