2012•Journal of Emergency in Traditional Chinese MedicineRequires access
Effect of Kangxianjian Decoction on Bcl-2 Protein Expression on Epilepsy Rats Induced by Pentylenetetrazol
Tan Wen-lan
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Abstract
Objective:to explore the influence of Kangxianjian Decoction on chronic epilepsy rats induced by pentylenetetrazole and the protection mechanism of Kangxianjian Decoction.Methods:Rats were randomly divided into the model group,the low dose of Kangxianjian Decoction group,the high dose of Kangxianjian Decoction and the valproate sodium pretreatment group.The expression of Bcl-2 in hippocampus of chronic epilepsy rats were detected by immunohistochemistry.Results:The seizure potential periods of the valproate sodium pretreatment group and the high dose of Kangxianjian Decoction group were significantly prolonged when they were compared with the model group.The Bcl-2 protein expressions in the low dose of Kangxianjian Decoction group,the high dose of Kangxianjian Decoction group and the valproate sodium pretreatment group were more than those in the model group.Conclusion:Kanxianjian Decoction has some protection effects on neuronal apoptosis induced by pentylenetetrazole.