Clinical study on Naoxueshu Oral Liquid combined with nimodipine in treatment of hypertensive cerebral hemorrhage

Objective To explore the clinical effect of Naoxueshu Oral Liquid combined with nimodipine in treatment of hypertensive cerebral hemorrhage. Methods The clinical data of 86 patients with hypertensive cerebral hemorrhage who were treated in Department of Neurosurgery of Affiliated Hospital of Yan'an University from April 2013 to April 2014 were retrospectively analyzed. The patients were divided into control and treatment groups according to the different therapeutic methods, and each group had 46 cases. All patients were performed minimally invasive removal of intracranial hematoma. The patients in the control group were continuous intravenous pumping Nimodipine Injection after the operation, with the dripping speed of 1 mg/h, once daily. After 7 d, they were po administered with Nimodipine Tablets, 40 mg/time, three times daily. The patients in the treatment group were po administered with Naoxueshu Oral Liquid on the basis of the control group, 10 m L/time, three times daily. The patients in two groups were treated for 7 d. After treatment, the efficacy was evaluated, and the changes of NIHSS scores, hematoma amount, edema volume around the hematoma, IL-4, IL-6, IL-10, and TNF-α in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 74.42% and 93.02%, respectively, and there were differences between two groups(P 0.05). After treatment, hematoma amount and edema volume around the hematoma in two groups were reduced, and NIHSS scores, IL-4, IL-6, IL-10, and TNF-α were significantly decreased, and the difference was statistically significant in the same group(P 0.05). These observed indexes in the treatment group were better than those in the control group, with significant difference between two groups(P 0.05). Conclusion Naoxueshu Oral Liquid combined with nimodipine has curative effect in treatment of hypertensive cerebral hemorrhage, and can reduce the level of inflammatory factors, also can promote the recovery of neural function, which has a certain clinical application value.