Effects of Nimodipine on hematoma absorption and neurofunction recovery in hypertensive cerebral hemorrhage

AIM:To explore the effects of Nimodipine on hematoma absorption and neurofunction recovery in hypertensive cerebral hemorrhage.METHODS:Forty-two patients with hypertensive cerebral hemorrhage hospitalized in 24 h were divided into study group(n=22)and control group(n=20)randomly.Based on conventional therapy,study group were treated with Nimodipine parenteral solution(10 mg/d).After 10 d,Nimodi-pine was given by peros or gastric tubes at the dosage of 40 mg each time(thrice per day),and it lasted for 1 month.And the hematoma quantity,encephaledema areas and CSS scores were compared between the 2 groups after treatment.And the clinic therapeutic effects were also compared.RESULTS:After 2-week treatment,the hematoma quantity and the hydroncus areas of the study group were significantly decreased compared with those of the control group(P0.05).The clinic effective rate(50.0%)and the overall effective rate(86.4%)were significantly higher than those of the control group with 20.0% and 55.0% respectively(P0.05).The CSS scores of the study group were signi-ficantly lower than those of the control group after 2-week treatment(P0.05),and the differences were more significant at 1 month and 3 months after treatment(P0.01).CONCLUSION:Early using Nimodipine for hypertensive cerebral hemorrhage has good effects on hematoma absorption,encephaledema relief and prognosis improvement.