Clinical Effects of Nimodipine in Treatment of Hypertensive Intracerebral Hemorrhage

Objective:To study the clinical effective of nimodipine in treatment of hypertensive intracerebral hemorrhage patients.Methods: Ninety patients with hypertensive Intranetcerebral hemorrhage were randomly divided into experimental group(45 cases) and control group(45 cases),and the patients in control group were treated with conventional therapy,and those in the experimental group were treated with nimodipine basis of conventional therapy.The clinical efficacy,the clinical neurological deficit score,clinical disability score,hematoma and edema volume change were observed before and after treatment and compared between the two groups.Results: The effective rates were 73.33% in the experimental group and 42.22% in the control group with statistically significant(P0.05).The clinical neurological deficit scores of the patients in experimental group were(18.58 ±3.06) before treatment and(12.31 ±2.74) after treatment,which were(18.28 ±2.97) before and(15.22 ±2.72) after treatment in the control group;The clinical disability scores of experimental group before and after treatment were(38.93 ±3.37) and(61.57 ±3.03),and were(37.51 ±4.962) and(43.48 ±7.19) in the control group before and after treatment;the hematoma volume of experimental group before and after treatment were(17.23 ±5.48) cm3 and(7.93 ±3.33) cm3,which were(17.60 ±5.46) cm3and(10.97 ±4.25) cm3for the control group before and after treatment;The edema volume experimental group before and after treatment were(7.73 ±3.20) cm3and(4.21 ±1.60) cm3,which were(7.83 ±3.19) cm3 and(5.67 ±1.82) cm3in the control group before and after treatment.Compared with these indexes before treatment,all of these indexes were improved after treatment(P0.01),moreover,these indexes were better in experiment group than those in control group after treatment(P0.01).Conclusions: Nimodipine can significantly reduce the hematoma volume and the volume of edema and improve the therapeutic effect and reduce the rate of neurologic impairment and disability occurrence on the intracerebral hemorrhage patients.