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2011•Unpublished venueRequires access

Advances of VEGF-C and VEGFR-3 in lymphangiogenesis of tumor

Jianquan Zhang

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Abstract

Vascular endothelial growth factor-C(VEGF-C) is the main control factor to promote lymphatic vessel formation and highly expressed in a variety of tumor tissue.Binding with its receptor-vascular endothelial growth factor-3(VEGFR-3),VEGF-C exclusively stimulates epithelial proliferation,and induces lymphangiogenesis lymphatic vessel expansion,thereby promoting tumor microlymphatic generation.Tumor lymphangiogenesis is a paramount component for tumor metastasis process.Recent experiments indicated that VEGF-C and VEGFR-3 secreted by tumor cells were able to activate tumor lymphangiogenesis and increase lymphatic metastasis.These findings will lead lymphangiogenesis and its resistant researches to be a focus in the study of lymphatic metastasis and a possible target of therapy.Lymphangiogenesis can make impact on the tumor metastasis process,and vice versa.

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What this paper is about

Vascular endothelial growth factor-C(VEGF-C) is the main control factor to promote lymphatic vessel formation and highly expressed in a variety of tumor tissue.Binding with its receptor-vascular endothelial growth factor-3(VEGFR-3),VEGF-C exclusively stimulates epithelial proliferation,and induces lymphangiogenesis lymphatic vessel expansion,thereby promoting tumor microlymphatic generation.Tumor lymphangiogenesis is a paramount component for tumor metastasis process.Recent experiments indicated that VEGF-C and VEGFR-3 secreted by tumor cells were able to activate tumor lymphangiogenesis and increase lymphatic metastasis.These findings will lead lymphangiogenesis and its resistant researches to be a focus in the study of lymphatic metastasis and a possible target of therapy.Lymphangiogenesis can make impact on the tumor metastasis process,and vice versa.

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Available abstract

Vascular endothelial growth factor-C(VEGF-C) is the main control factor to promote lymphatic vessel formation and highly expressed in a variety of tumor tissue.Binding with its receptor-vascular endothelial growth factor-3(VEGFR-3),VEGF-C exclusively stimulates epithelial proliferation,and induces lymphangiogenesis lymphatic vessel expansion,thereby promoting tumor microlymphatic generation.Tumor lymphangiogenesis is a paramount component for tumor metastasis process.Recent experiments indicated that VEGF-C and VEGFR-3 secreted by tumor cells were able to activate tumor lymphangiogenesis and increase lymphatic metastasis.These findings will lead lymphangiogenesis and its resistant researches to be a focus in the study of lymphatic metastasis and a possible target of therapy.Lymphangiogenesis can make impact on the tumor metastasis process,and vice versa.

Key concepts: Lymphangiogenesis, Vascular endothelial growth factor C, Lymphatic system, Lymphatic Endothelium, Lymphatic vessel, Metastasis, Cancer research, VEGF receptors

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