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The Relationship of Tumor Lymphangiogenesis and Metastasis

HE Jian-y

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Abstract

Tumor lymphangiogenesis is a paramount component for tumor metastasis process.Recent experiments indicated that VEGF-C and VEGF-D secreted by tumor cells were able to activate tumor lymphangiogenesis and increase lymphatic metastasis.These findings will lead lymphangiogenesis and its resistant researches to be a focus in the study of lymphatic metastasis and a possible target of therapy.The two have an intimate relationship that lymphangiogenesis can make impact on the tumor metastasis process,and vice versa.

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What this paper is about

Tumor lymphangiogenesis is a paramount component for tumor metastasis process.Recent experiments indicated that VEGF-C and VEGF-D secreted by tumor cells were able to activate tumor lymphangiogenesis and increase lymphatic metastasis.These findings will lead lymphangiogenesis and its resistant researches to be a focus in the study of lymphatic metastasis and a possible target of therapy.The two have an intimate relationship that lymphangiogenesis can make impact on the tumor metastasis process,and vice versa.

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Available abstract

Tumor lymphangiogenesis is a paramount component for tumor metastasis process.Recent experiments indicated that VEGF-C and VEGF-D secreted by tumor cells were able to activate tumor lymphangiogenesis and increase lymphatic metastasis.These findings will lead lymphangiogenesis and its resistant researches to be a focus in the study of lymphatic metastasis and a possible target of therapy.The two have an intimate relationship that lymphangiogenesis can make impact on the tumor metastasis process,and vice versa.

Key concepts: Lymphangiogenesis, Metastasis, Lymphatic system, Medicine, Cancer research, Lymphatic Endothelium, VEGF receptors, Oncology

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