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Expression and clinical significance of C-erbB2,PCNA,ER,PR in 126 cases of breast carcinoma

Jingwu Li

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Abstract

s] Objective:To investigate the relationship between expression of C-erbB2,PCNA,ER,PR and clinic-pathologic characters of human breast carcinoma.Methods:The expressions of C-erbB2,PCNA,ER,PR were studied in 126 cases of breast carcinoma by using SP immunohistochemistry.Results:The positive rates of expression of C-erbB2,PCNA,ER,PR in breast carcinoma were 36.5%,95.2%,65.1%,54% respectively.The positive rates and expression intensity of C-erbB2,PCNA,ER,PR in breast carcinoma had no significant correlation with the age,lymph node metastasis,tumor size,pTNM stage of the patient(P﹥0.05).The positive rates and expression intensity of C-erbB2,PCNA in breast carcinoma had significant correlation with the differentiation degree of the patient(P﹤0.05).The expression of C-erbB2 was negatively associated with ER,PR(r=-0.344,P=0.000;r=-0.226,P=0.011).Conclusion:Over-expression of C-erbB2 and pCNA showed poor prognosis and they can be markers for estimating the prognosis of breast cancer.

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s] Objective:To investigate the relationship between expression of C-erbB2,PCNA,ER,PR and clinic-pathologic characters of human breast carcinoma.Methods:The expressions of C-erbB2,PCNA,ER,PR were studied in 126 cases of breast carcinoma by using SP immunohistochemistry.Results:The positive rates of expression of C-erbB2,PCNA,ER,PR in breast carcinoma were 36.5%,95.2%,65.1%,54% respectively.The positive rates and expression intensity of C-erbB2,PCNA,ER,PR in breast carcinoma had no significant correlation with the age,lymph node metastasis,tumor size,pTNM stage of the patient(P﹥0.05).The positive rates and expression intensity of C-erbB2,PCNA in breast carcinoma had significant correlation with the differentiation degree of the patient(P﹤0.05).The expression of C-erbB2 was negatively associated with ER,PR(r=-0.344,P=0.000;r=-0.226,P=0.011).Conclusion:Over-expression of C-erbB2 and pCNA showed poor prognosis and they can be markers for estimating the prognosis of breast cancer.

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Available abstract

s] Objective:To investigate the relationship between expression of C-erbB2,PCNA,ER,PR and clinic-pathologic characters of human breast carcinoma.Methods:The expressions of C-erbB2,PCNA,ER,PR were studied in 126 cases of breast carcinoma by using SP immunohistochemistry.Results:The positive rates of expression of C-erbB2,PCNA,ER,PR in breast carcinoma were 36.5%,95.2%,65.1%,54% respectively.The positive rates and expression intensity of C-erbB2,PCNA,ER,PR in breast carcinoma had no significant correlation with the age,lymph node metastasis,tumor size,pTNM stage of the patient(P﹥0.05).The positive rates and expression intensity of C-erbB2,PCNA in breast carcinoma had significant correlation with the differentiation degree of the patient(P﹤0.05).The expression of C-erbB2 was negatively associated with ER,PR(r=-0.344,P=0.000;r=-0.226,P=0.011).Conclusion:Over-expression of C-erbB2 and pCNA showed poor prognosis and they can be markers for estimating the prognosis of breast cancer.

Key concepts: Proliferating cell nuclear antigen, Breast carcinoma, Immunohistochemistry, Breast cancer, Medicine, Carcinoma, Oncology, Internal medicine

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Expression and clinical significance of C-erbB2,PCNA,ER,PR in 126 cases of breast carcinoma — Research Paper | ScholarLens