Analysis of serum total bile acids in neonatal jaundice

Objective To analyze the clinical significance of serum total bile acid determination in the laboratory diagnosis of jaundice in the newborns.Method For 98 cases of jaundice(19 cases of physiological jaundice,79 cases of pathologic jaundice),and 36 cases in the control group,were detected the serum total bile acid levels and compared.Results The serum total bile acid(TBA) levels were(7.23 ±2.98) μmol/L,(36.75±29.56) μmol/L and(7.48±7.25) μmol/L,respectively in the control group,TBA pathologic jaundice group and TBA physiological jaundice group.The serum TBA level in TBA pathologic jaundice group was obviously higher than the control group(P0.01);the difference between the control group and TBA physiological jaundice group was not statistically significant(P0.05).Conclusion In the laboratory diagnosis of neonatal jaundice,determination of serum total bile acid has highly specificity,provides evidence for clinical diagnosis and treatment,which shows some clinical value in reducing the complication incidence of children with hyperbilirubinemia.