The Expression and Clinical Significance of P-gp、GST-Л、p53 and CD44v6 Gene Protein in Lung Cancer

Objective To explore the expression and clinical significance of P-gp、GST-Л and p53 and CD44v6 gene protein in human lung cancer.Methods The expression of P-gp、GST-Л p53 and CD44v6 protein were detected in 60 cases of lung cancer tissue with SP immunohistochemical method and analyzed.Results The result showed that: ① the positive expression of P-gp and GST-Л separately were 69.8% and 73.6% in NSCLC, which were much higher than the positive expression in SCLC( 14.3%)(P 0.05),compared with adenocarcinoma and squamous carcinoma、SCLC, the positive rate of P-gp and GST-Л in adenocarcinoma were higher(P 0.05).②The positive rate of CD44v6 gene production is 65.0%, which has a significant positive correlation with lymph node metastasis (P 0.05).③The coexpression rate of P-gp and GST-Л is 41.7%, P-gp significantly positively correlated with GST-Л. The coexpression rate of P-gp and p53 is 48.3%, P-gp had obviously positive correlation with p53.Conclusion The over- expression of P-gp、GST-Л and p53 in human lung cancer made it important to influence tumor resistance.The over- expression of CD44v6 may be the good indicator for predicting metastasis and prognosis of lung cancer.