Expression of P-gp,GST-Л,TOPOII gene protein in lung cancer

Objective: To explore the expression and clinical significance of P-gp,GST-Л and TOPOⅡprotein in human lung cancer. Methods:The expression of P-gp,GST-Л and TOPOⅡprotein were detected in 60 cases of lung cancer tissue with S-P immunohistochemical method.Results:The result showed that: ① the positive expression of GST-Лand P-gp separately were 75% and 70.8% in NSCLC ,which were much higher than the positive expression in SCLC(P0.05),compared with squamous carcinoma and adenocarcinoma, the positive rate of GST-Л and P-gp in adenocarcinoma were higher(P0.01). But the positive rate of TOPOⅡ in adenocarcinoma was significantly lower than that in squamous carcinoma and SCLC (P0.05).②The coexpression rate of only 2 MDR gene production and only 2 or 3 MDR gene production separately were 61.1% and 80%,which exceeded apparently more than individual expression rate 11.7% (P-gp)and 10%(TOPOⅡ); P-gp significantly positively correlated with GST-Л; P-gp and GST-Л separately had obviously negative correlation with TOPOⅡ. Conclusion:The over- expression of P-gp,GST-Л and the lower -expression of TOPOⅡ in human lung cancer made it important to influence tumor resistance , signal cooperated with many genes,but the coexpression of many genes mostly.