2008•Zhongguo yaoke daxue xuebaoRequires access
Preparation and in vitro release of nifedipine delayed-onset sustained-release tablets
Jianping Zhou
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Abstract
Aim:To explore the preparation methods of nifedipine delayed-onset sustained-release tablets in accordance with chronopharmacology.Methods:Delayed-onset sustained-release tablets were prepared by direct compression of the powder mixture containing insoluble materials and coated using dry powder coating.The formulation was optimized by using the orthogonal design.Results:The lag time of the tablets was about 5-6 h.It was indicated that matrix erosion attribute to the major mechanism in the tablets release.Conclusion:We obtain the practical formulation and manufacturing processing of nifedipine delayed-onset sustained-release tablets and the tablet quality is stable.