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2010•Journal of Oral Science ResearchRequires access

Expression and Signifcance of HIF-1α and MMP-7 in Parotid Adenoid Cystic Carcinoma

Yu Lan

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Abstract

Objective: To study the correlation between expression of HIF-1α and MMP-7 and biological behavior of parotid adenoid cystic carcinoma.Methods: The expression of HIF-1α and MMP-7 in 21 cases of ACC,15 cases of plemorphic adenoma(PA) and 15 cases of normal parotid tissue were detected by the immunohistochemistry S-P method.Results: The positive rates of HIF-1α and MMP-7 in adenoid cystic carcinoma were 80.95% and 76.19%.The expression of HIF-1α and MMP-7 was closely correlated with nerve invasion or lymph node metastasis(P0.05).A relative correlation was found between expressions of HIF-1α and MMP-7(rs=0.458,P0.01).Conclusion: The expression of HIF-1α and MMP-7 might be related to biologic behavior of adenoid cystic carcinoma.

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Objective: To study the correlation between expression of HIF-1α and MMP-7 and biological behavior of parotid adenoid cystic carcinoma.Methods: The expression of HIF-1α and MMP-7 in 21 cases of ACC,15 cases of plemorphic adenoma(PA) and 15 cases of normal parotid tissue were detected by the immunohistochemistry S-P method.Results: The positive rates of HIF-1α and MMP-7 in adenoid cystic carcinoma were 80.95% and 76.19%.The expression of HIF-1α and MMP-7 was closely correlated with nerve invasion or lymph node metastasis(P0.05).A relative correlation was found between expressions of HIF-1α and MMP-7(rs=0.458,P0.01).Conclusion: The expression of HIF-1α and MMP-7 might be related to biologic behavior of adenoid cystic carcinoma.

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Available abstract

Objective: To study the correlation between expression of HIF-1α and MMP-7 and biological behavior of parotid adenoid cystic carcinoma.Methods: The expression of HIF-1α and MMP-7 in 21 cases of ACC,15 cases of plemorphic adenoma(PA) and 15 cases of normal parotid tissue were detected by the immunohistochemistry S-P method.Results: The positive rates of HIF-1α and MMP-7 in adenoid cystic carcinoma were 80.95% and 76.19%.The expression of HIF-1α and MMP-7 was closely correlated with nerve invasion or lymph node metastasis(P0.05).A relative correlation was found between expressions of HIF-1α and MMP-7(rs=0.458,P0.01).Conclusion: The expression of HIF-1α and MMP-7 might be related to biologic behavior of adenoid cystic carcinoma.

Key concepts: Adenoid cystic carcinoma, Lymph node metastasis, Immunohistochemistry, Pathology, Medicine, Matrix metalloproteinase, Carcinoma, Adenoid

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Expression and Signifcance of HIF-1α and MMP-7 in Parotid Adenoid Cystic Carcinoma — Research Paper | ScholarLens