Expression and clinical significance of MMP-2 and MVD in adenoid cystic carcinoma

Objective To study the expression and clinical significance of matrix metalloproteinase-2(MMP-2)and endoglin(CD105)in cancer of adenoid cystic carcinoma(ACC)and explore the correlation of MMP-2 with MVD which was marked by CD105.Methods Immunohistochemistry was used to measure the expression of CD105 and MMP-2 in normal tissues of salivary gland,pleomorphic adenoma(PA)and adenoid cystic carcinoma(ACC),calculation of MVD and MMP-2;the data was analyzed by SPSS(13.0)software.Results The difference of the MVD in the normal tissues of salivary gland,pleomorphic adenoma and adenoid cystic carcinoma was significant,so was MMP-2;the count of MVD showed significant correlation with size of the tissues,stage of the disease,type of pathological and neurological symptoms(P 0.05);the difference of MMP-2 in different types of pathological and sizes of the tissues were significant(P 0.05);the difference of MVD which was divided by the count of MMP-2 was significant(P 0.05).Conclusion MMP-2 and CD105 are highly expressed in adenoid cystic carcinoma tissues at protein level;the MVD marked by CD105 significantly correlates with MMP-2;they might become promising targets for adenoid cystic carcinoma.