Influence of Insulin Pump Treatment on the Level of Blood Glucose,Serum Lipids,Oxidative Stress and the Relation between Islet β Cell and Superoxide Dismutase in Newly Diagnosed Type 2 Diabetic Patients

Objective To explore the influence of continuous subcutaneous insulin infusion(CSII) on the level of blood glucose,serum lipids,oxidative stress and the relation between islet β cell and superoxide dismutase(SOD) in newly diagnosed type 2 diabetic patients.Methods A total of 60 newly diagnosed T2DM patients who had fasting plasma glucose(FPG) ≥10 mmol/L and had never been treated with oral antidiabetic drugs or insulin were included and treated with insulin pump for 14 days.FPG,2 hour postprandial plasma glucose(2 hPG),glycated albumin(GA),fasting insulin(FINS),triacylglycerol(TG),SOD and malonaldehyde(MDA) were measured before and after insulin pump treatment.Insulin resistance index(HOMA-IR) and insulin secretion index(HOMA-β) were compared before and after the treatment.Results The level of FPG,2 hPG,GA,TG,MDA and HOMA-IR were significant lower(P0.01),while SOD and HOMA-β were significantly improved(P0.01) after the treatment.HOMA-β was positively associated with the SOD level(R=0.51,R2=0.26,P0.01).Conclusion In newly diagnosed T2DM with severe hyperglycemia,intensive insulin pump treatment could effectively control the blood sugar and fat,improve insulin resistance,restore pancreatic β cells function and increase the SOD level,which can reduce the damage to pancreatic β cells caused by oxidative stress.