Effects of Short-term Insulin Pump Intensive Treatment on Metabolism of Glucose and Lipid in Newly Diagnosed Type 2 Diabetic Patients

To evaluate the effect of short term insulin pump intensive treatment on metabolism of glucose and lipid in newly diagnosed type 2 diabetic patients with severe hyperglycemia.Eighty five newly diagnosed type 2 diabetic patients with FBG 11.1 mmol/L were treated by 2 weeks insulin pump therapy. Plasma glucose, GHbA1C, insulin, proinsulin, lipid profiles and free fatty acids (FFA) were measured and an intravenous glucose tolerance test (IVGTT) was performed before and after insulin pump treatment. The results of FBG, 2hBG, GHbA1C, lipid profiles, FFA, first phase insulin secretion, proinsulin, proinsulin/insulin ratio, Homa βand Homa IR were compared. Excellent control of FBG and 2hBG was achieved stably in 82 /85 patients in 3.45 days and 6.15 days after insulin pump therapy. The lipid profiles were obviously improved. The FFA levels were reduced remarkably from(0.67±0.24)mmol/L to (0.60±0.19)mmol/L. After 2 weeks insulin pump intensive treatment, beta cell function was dramatically improved: the first phase insulin secretion of most patients restored in different degrees. The mean area under the curve(AUC) of insulin was enhanced remarkably, (892±386) pmol/L before CSII to(1 318±518) pmol/L after CSII(P=0.000). Homa βwere significantly increased, plasma proinsulin, proinsulin/insulin ratio and Homa IR were decreased obviously. [Conclusion]Excellent glycemic control and improvement of lipid profiles and lowering of FFA along with increased beta cell function and decreased insulin resistance can be induced by short term insulin pump intensive therapy in newly diagnosed type 2 diabetic patients with severe hyperglycemia.