The Effect of Short-term Acting Insulin plus Long-term Intensive Insulin On Islet Function and Oxidative Stress of Newly Diagnosed Type 2 Diabetic Patients

Objective: To investigate the effect of islet function and oxidative stress of short-term acting insulin and long-term intensive insulin in the treatment of newly diagnosed type 2 diabetic patients.Methods: 30 cases of newly diagnosed patients with type 2 diabetes were chosen.On the basis of general treatment,we used short-term insulin + long-term insulin therapy program.Serum markers,including fasting blood glucose(FBG),2-hour postprandial blood glucose(2h PPG),glycated hemoglobin(HbA1c),serum C-peptide(FCP),islet cell function parameters before and after treatment were detected and compared.Insulin area under the curve(AUG),insulin resistance index(HOMA-IR),insulin and C-peptide levels,beta cell function in the homeostasis model assessment(HOMA-B),I30/G30,as well as oxidative stress indicators including malondialdehyde(MDA) and superoxidedismutase(SOD) were compared.Results: 1.Compared with before treatment,the levels of FPG,2 h average PPG,HbA1c,AUG,HomaB HomaIR and I30/G30 after treatment were significantly improved,which was statistically significant(P0.05).After treatment,the oral glucose tolerance test 0h,1 h and 2 h insulin levels and C-peptide levels increased significantly compared with before treatment,with significant differences(P0.05).2.After treatment,the MDA levels significantly decreased,the SOD levels significantly increased,which were statistically significant(P0.05).Conclusion: In the treatment of newly diagnosed type 2 diabetic patients,short-term acting insulin + long-term intensive insulin treatment programs can significantly improve islet function,as well as reduce oxidative stress.