Effect of Dietary Fiber in Apium graveolens L. on Blood Fat of Hyperlipemia Rats

Objective To establish a hyperlipemia rat model and to investigate the effect of dietary fibe(rDF)in Apium graveolens L.(AGL)on indexes of blood fat in hyperlipemia rats.Methods Wistar rats were randomly divided into normal group,model group,Jiangzhiling group,low-,middle-and high-dose DF-AGL groups.Hyperlipemia rat model was established by feeding high-fat forage for 10 days.The normal group and the model group were given the same volume of saline,and the other groups were given corresponding drugs.After 18 days,the body weight was weighted and the levels of total cholesterol(TC),triglyceride(TG)and high-density lipid cholestero(lHDL-C)were determined by enzyme method to evaluate the effect of DF-AGL in decreasing blood lipid.Results After feeding with high-fat forage for 10 days,the levels of TC,TG and weight gain in the model group were increased obviously compared with those of normal group(P0.05),indicating the successful establishment of rat models of hyperlipemia.After intragastric administration of different doses of DF-AGL suspension for 18 days,the levels of TC and TG in hyperlipemia rats were increased obviously(P0.05 compared with the model group);the levels of TC and atherogenic index(AI) in low-and middle-dose DF-AGL groups were decreased compared with Jiangzhiling group(P0.05).The level of TG in low-dose DF-AGL group was statistically significant compared with Jiangzhiling group(P0.05),and the levels of TC,TG and AI in high-dose DF-AGL group were statistically significant compared with low-dose DF-AGL group(P0.05).Conclusion The levels of TC and TG decrease with the increase of DF-AGL dose,indicating a clear dose-effect relationship.DF-AGL is effective in modulating the blood fat levels.