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2014•Lishizhen Medicine and Materia Medica ResearchRequires access

Effects of Xinshubao on Blood Lipid Levels in Rat Model of Hyperlipemia

QI Xu-fen

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Abstract

Objective To explore the effects of Xinshubao on blood lipid levels in rat model of hyperlipemia. Methods SD rats were fed with high fat diet for 8 weeks to establish hyperlipemia model. Rats were then set up 3 groups from 9th week to 14th week: control group was fed with high fat diet,experiment group 1 was fed with normal diet and gavaged with Xinshubao,and experiment group 2 was fed with high fat diet and gavaged with Xinshubao. Serum was isolated to examine the levels of triglyceride( TG),cholesterol( TC),high density lipoprotein( HDL),low density lipoprotein( LDL) and blood glucose suing kits. Results ①In comparison with control group,Xinshubao can significantly decrease the levels of TC and LDL; ②Xinshubao had no significant effects on the levels of TG,HDL and blood glucose compared to control group. Conclusion Xinshubao can decrease blood lipid levels by suppressing TC and LDL levels in rat model of hyperlipemia.

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What this paper is about

Objective To explore the effects of Xinshubao on blood lipid levels in rat model of hyperlipemia. Methods SD rats were fed with high fat diet for 8 weeks to establish hyperlipemia model. Rats were then set up 3 groups from 9th week to 14th week: control group was fed with high fat diet,experiment group 1 was fed with normal diet and gavaged with Xinshubao,and experiment group 2 was fed with high fat diet and gavaged with Xinshubao. Serum was isolated to examine the levels of triglyceride( TG),cholesterol( TC),high density lipoprotein( HDL),low density lipoprotein( LDL) and blood glucose suing kits. Results ①In comparison with control group,Xinshubao can significantly decrease the levels of TC and LDL; ②Xinshubao had no significant effects on the levels of TG,HDL and blood glucose compared to control group. Conclusion Xinshubao can decrease blood lipid levels by suppressing TC and LDL levels in rat model of hyperlipemia.

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Available abstract

Objective To explore the effects of Xinshubao on blood lipid levels in rat model of hyperlipemia. Methods SD rats were fed with high fat diet for 8 weeks to establish hyperlipemia model. Rats were then set up 3 groups from 9th week to 14th week: control group was fed with high fat diet,experiment group 1 was fed with normal diet and gavaged with Xinshubao,and experiment group 2 was fed with high fat diet and gavaged with Xinshubao. Serum was isolated to examine the levels of triglyceride( TG),cholesterol( TC),high density lipoprotein( HDL),low density lipoprotein( LDL) and blood glucose suing kits. Results ①In comparison with control group,Xinshubao can significantly decrease the levels of TC and LDL; ②Xinshubao had no significant effects on the levels of TG,HDL and blood glucose compared to control group. Conclusion Xinshubao can decrease blood lipid levels by suppressing TC and LDL levels in rat model of hyperlipemia.

Key concepts: Triglyceride, Blood lipids, Endocrinology, Internal medicine, High-density lipoprotein, Cholesterol, Total cholesterol, Low-density lipoprotein

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