Effects of Dietary Fiber in Oat Bran on Blood Glucose and Blood Lipid in Experimental Type-2 Diabetes Mellitus Rats

Objective To study the effects of dietary fiber(DF) in Oat bran on blood glucose and blood lipid in rats with experiment type-2 diabetes mellitus.Methods 50 wistar rats(194.4±5.3g) are divided into 5 groups base on their body weight.Every group has 10 rats(half male and half female).The control group(group A) is fed normal diet.The other four groups are injected with lower dose(25mg/kg bw) of streptozotocin(STZ) and fed a diet with high calorie and high fat.After formation of the diabetes model,week the three concentration of DF all decrease fasting group B(T2DM model group) is fed a diet with high calorie and high fat,and group C,D,E are fed 30% DF,40% DF and 60% DF respectively.The effects of DF on metabolism of glucose and lipid,and availability of food are observed.Results ①The difference of food availability is statistically significant.Compared group B with the other four groups respectively,the differences are all significant ②Before the injection of STZ(0W),the level of blood glucose and lipid in every group are statistically same.But on the eighth blood glucose(FBG),Triglycerides,(TG),Total cholesterol(TC),and Low density lipid-cholesterol(LDL-C),significantly,and increase High density lipid-cholesterol(HDL-c) at the same time.The effects of 40%,60% DF stronger than 30% DF.③The glucose tolerance curve of every group is significantly different.The curve of group A and B are steep,while group C,D and E are relatively smooth.Conclusion DF can decrease the blood glucose and blood lipid.