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Effect of Oral Ambroxol on Pharmacokinetics of Aminophyllin

Wenli Liu, Wenfang Zhang

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Abstract

OBJECTIVE:To study whether there is interaction between ambroxol hydrochloride and aminoˉphylline.METHODS:16volunteer were randomly divided into trial group and control group.The blood concentration of amin_ ophylline was determinated with HPLC method,then the main parameters of pharmacokinetics of aminophylline were calculated with3p97software.RESULTS:The main parameters of pharmacokinetics of aminophylline in trial and control group were:K e (0.062±0.023)/h and(0.0905±0.013)/h;V(22.83±7.85)and(23.27±3.78)L;T 1/2 (12.51±4.2)and(7.77±0.89)h;AUC 0～21 (426.59±186.92)and(245.74±48.6)(mg·h)/L;CL(s)(23.17±9.83)and(34.84±6.00)ml/min respectiveˉly.CONCLUSION:Although ambroxol hydrochloride did not influence the distribution of aminophylline,but it could prolong the half time of aminophylline and increase the stagnation time of aminophylline in vivo.

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OBJECTIVE:To study whether there is interaction between ambroxol hydrochloride and aminoˉphylline.METHODS:16volunteer were randomly divided into trial group and control group.The blood concentration of amin_ ophylline was determinated with HPLC method,then the main parameters of pharmacokinetics of aminophylline were calculated with3p97software.RESULTS:The main parameters of pharmacokinetics of aminophylline in trial and control group were:K e (0.062±0.023)/h and(0.0905±0.013)/h;V(22.83±7.85)and(23.27±3.78)L;T 1/2 (12.51±4.2)and(7.77±0.89)h;AUC 0～21 (426.59±186.92)and(245.74±48.6)(mg·h)/L;CL(s)(23.17±9.83)and(34.84±6.00)ml/min respectiveˉly.CONCLUSION:Although ambroxol hydrochloride did not influence the distribution of aminophylline,but it could prolong the half time of aminophylline and increase the stagnation time of aminophylline in vivo.

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Available abstract

OBJECTIVE:To study whether there is interaction between ambroxol hydrochloride and aminoˉphylline.METHODS:16volunteer were randomly divided into trial group and control group.The blood concentration of amin_ ophylline was determinated with HPLC method,then the main parameters of pharmacokinetics of aminophylline were calculated with3p97software.RESULTS:The main parameters of pharmacokinetics of aminophylline in trial and control group were:K e (0.062±0.023)/h and(0.0905±0.013)/h;V(22.83±7.85)and(23.27±3.78)L;T 1/2 (12.51±4.2)and(7.77±0.89)h;AUC 0～21 (426.59±186.92)and(245.74±48.6)(mg·h)/L;CL(s)(23.17±9.83)and(34.84±6.00)ml/min respectiveˉly.CONCLUSION:Although ambroxol hydrochloride did not influence the distribution of aminophylline,but it could prolong the half time of aminophylline and increase the stagnation time of aminophylline in vivo.

Key concepts: Aminophylline, Pharmacokinetics, Pharmacology, Hydrochloride, Medicine, Distribution (mathematics), Chemistry, Anesthesia

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