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Study on Pharmacokinetics of Aminophylline in Rat

Minjie Wei

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Abstract

The pharmacokinetic process about the concentration in rat plasma of aminophylline was investigated by HPLC.HPLC Analysis was carried out by using Hypersil BDS C18 column(4.6 mm×200 mm,5 μm)and methanol-water(24∶76) as the mobile phase,and the UV detection wavelength was 274 nm.Results showed that,the concentration-time data of aminophylline were all in accordance with an open two-compartment model.The main pharmacokinetics parameters were as follows:tmax was(1.083±0.195)h,cmax was(74.349±7.599)mg·L-1,t1/2 was(3.283±0.631)h,AUC0~∞ was(457.664±61.173)mg·L-1·h-1,MRT0~∞ was(5.265±0.610)h,CL was(0.046±0.007)L·kg-1·h-1.The method was simple,accurate,highly sensitive and reproducible.It was a good reference for pharmacokinetics of aminophylline in human bodies.

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What this paper is about

The pharmacokinetic process about the concentration in rat plasma of aminophylline was investigated by HPLC.HPLC Analysis was carried out by using Hypersil BDS C18 column(4.6 mm×200 mm,5 μm)and methanol-water(24∶76) as the mobile phase,and the UV detection wavelength was 274 nm.Results showed that,the concentration-time data of aminophylline were all in accordance with an open two-compartment model.The main pharmacokinetics parameters were as follows:tmax was(1.083±0.195)h,cmax was(74.349±7.599)mg·L-1,t1/2 was(3.283±0.631)h,AUC0~∞ was(457.664±61.173)mg·L-1·h-1,MRT0~∞ was(5.265±0.610)h,CL was(0.046±0.007)L·kg-1·h-1.The method was simple,accurate,highly sensitive and reproducible.It was a good reference for pharmacokinetics of aminophylline in human bodies.

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Available abstract

The pharmacokinetic process about the concentration in rat plasma of aminophylline was investigated by HPLC.HPLC Analysis was carried out by using Hypersil BDS C18 column(4.6 mm×200 mm,5 μm)and methanol-water(24∶76) as the mobile phase,and the UV detection wavelength was 274 nm.Results showed that,the concentration-time data of aminophylline were all in accordance with an open two-compartment model.The main pharmacokinetics parameters were as follows:tmax was(1.083±0.195)h,cmax was(74.349±7.599)mg·L-1,t1/2 was(3.283±0.631)h,AUC0~∞ was(457.664±61.173)mg·L-1·h-1,MRT0~∞ was(5.265±0.610)h,CL was(0.046±0.007)L·kg-1·h-1.The method was simple,accurate,highly sensitive and reproducible.It was a good reference for pharmacokinetics of aminophylline in human bodies.

Key concepts: Aminophylline, Pharmacokinetics, Chemistry, High-performance liquid chromatography, Cmax, Chromatography, Pharmacology, Biochemistry

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