Effect of oral ambroxol on pharmacokinetics of terbutaline

Objective:To study the effect of ambroxol on the pharmacokinetics of terbutaline in healthy volunteers.Method: 20 volunteers were randomly divided into trial group and control group.The blood concentration of terbutaline was determinated with HPLC method,the main pharmacokinetics parameters of terbutaline were calculated with 3p97 software. Results: The main parameters of pharmacokinetics of terbutaline in trial and control group were:t1/2(5.56±0.42)h and(3.18±0.29)h;AUC0～∞(59.59±11.67)h·ng·mL-1 and(47.18±10.41)h·ng·mL-1;tmax(2.33±1.05)h and(3.04±1.59) h;Cmax(10.51±3.02)ng·mL-1 and(8.23±2.36)ng·mL-1 respectively.Conclusion: Ambroxol hydrochloride has an significant influence on the pharmacokinetics of terbutaline with extending of elimination half-life and retention time in vivo.