Clinical Efficacy and Prognostic Value of Atorvastatin on Patients with Acute Cerebral Infarction

Objective To investigate the clinical efficacy and early prognostic value of atorvastatin in patients with acute cerebral infarction.Methods 70 patients with acute cerebral infarction were randomly divided into control group and atorvastatin group.The patients in the control group received conventional therapy,while those in the atorvastatin group was administrated orally with 20mg of Atorvastatin.The indices of total cholesterol(TC),triglyceride(TG),lowerdensity lipoprotein-cholesterol(LDL-C),high density lipoprotein-cholesterol(HDL-C),C-reactive protein(CRP),carotid artery ultrasound and the carotid artery intima-media thickness(IMT) were compared respectively in the groups before and after treatment of the first month and the third month.Plaque area and plaque Crouse points were detected in patients with cerebral infarction.All patients were followed up for 6 months.Results(1) After 1 month treatment,LDL-C and CRP levels in atorvastatin group significantly reduced compared with those before treatment(P0.01) and CRP also decreased in the control group(P0.05).After 3 months treatment in the atorvastatin group,TC and LDL-C and CRP significantly reduced compared with those before treatment and after 1 month treatment(P0.05).(2)There was no significant difference on IMT between the two groups before treatment(P0.05),and after 1 month treatment the above was also no significant difference(P0.05).After 3 months treatment in the atorvastatin group,the IMT significantly decreased(P0.01);Plaque area was no significant difference between the two groups(P0.05);Crouse score in the atorvastatin group were significantly lower than that in the control group(P0.05).(3)ADL score significantly increased in patients of atorvastatin group after six months treatment(P0.05).Conclusion Atorvastatin had early lipid-lowering and antiinflammatory effects on patients with acute cerebral infarction.It could stabilize or reverse the carotid artery plaque and improve the early prognosis.