Curative Effect of Clopidogrel Combined with Atorvastatin Calcium in the Treatment of Patients with Acute Cerebral Infarction

Objective: To contrast the curative effect of clopidogrel combined with atorvastatin calcium with that of atorvastatin calcium only in patients with acute cerebral infarction. Methods: 110 cases of acute cerebral infarction were randomly divided into the treatment group( 55 cases) and the control group( 55 cases). The treatment group was given clopidogrel and atorvastatin calcium on the basis of conventional treatment and the control group was given clopidogrel only. Blood lipid level and carotid intima-media thickness( IMT) of the patients from both the groups were assayed,respectively,three months before and after the treatment. A six-month follow-up was made to assess the defect of nerve function and the daily living skills of the patients with National Institutes of Health Stroke Scale( NIHSS) and the activities of daily living Scale( ADL). Results: The indices of Total cholesterol( TC),triglyceride( TG) and lower ddensity lipoprotein-cholesterol( LCD-C) all decreased three months after treatment in the treatment group( P 0. 05); the indices of TC and lipoprotein-cholesterol( LCD-C) decreased three months after the treatment in the control group( P 0. 05); the indices of IMT decreased three months after the treatment in the treatment group( P 0. 05). The scores of ADL of the patients from both the groups were increased six months after the treatment,with the ADL score higher in the treatment group than that in the control group( P 0. 05),while the scores of NIHSS of the patients from both the groups were decreased six months after the treatment,with NIHSS score lower in the treatment group than that in the control group( P 0. 05). Conclusion: Clopidogrel combined with atorvastatin calcium therapy can effectively lower the blood lipid level,thin down IMT,improve the daily living ability and restore the nervous function.