The study on the effect of atorvastatin on the blood lipid level and carotid artery intima-media thickness in patients with cerebral infarction

Objective To observe the effect of atorvastatin on the blood lipid level and carotid artery intimamedia thickness in patients with cerebral infarction who have taken atorvastatin for a long time. Methods 120 cases of the patients with cerebral infarction treated in our hospital from January 2012 to January 2014 were selected and randomly divided into 2 groups, 60 cases in each group. The patients in two groups were given routine treatment and nursing measures, but 60 cases of the patients in study group patients were also asked to take Atorvastatin tablets(20mg was taken every evening and it should last for 12 months) as part of the treatment while the patients in the control group were also asked to take Simvastatin tablets(20mg was taken every evening and it should last for 12 months). The Serum lipids and carotid artery intima-media thickness of the patients in two groups before and after treatment were compared. Results Six months after taking the medicine, the blood TC, TG levels of the patients in two groups were decreased significantly(P 0.01), but the blood TC, TG levels of the patients in the study group demonstrated a significantly greater reduction(P 0.05). The blood LDL level of the patients in the study group after administration decreased significantly(P 0.01) and their blood HDL level increased than before(P 0.05). There were no significant changes in The LDL and HDL level of the patients in the control group before and after treatment(P0.05). Conclusion That the patients with cerebral infarction take atorvastatin for a long time can effectively improve the blood lipid level and can reduce the risk of carotid atherosclerosis. This treatment is worthy of clinical application.