Human papilloma virus infections and subtype analysis of patients with cervical lesions

OBJECTIVE To investigate the human papilloma virus infections of patients with cervical lesions and its subtype,so as to provide objective basis for prevention and treatment of diseases.METHODS We selected 130cases of patients with cervical lesions enrolled from January 2010 to December 2012 as research subjects and detected21HPV subtypes of the patient′s cervical exfoliated cells using flow-through hybridization and gene chip technique.RESULTS 96cases of patients were discovered HPV infections among 130patients with cervical lesions with an infection rate of 73.85%.Of which,the high-risk HPV infection rate of gervicitis/genital warts was 54.72%,and the low-risk HPV infection rate was 15.09%.High-risk HPV infection rate and low-risk HPV infection rate of cervical intraepithelial neoplasia(CIN)in patients were 67.69% and 7.69%,respectively.The lowrisk HPV infections of patients with ervical cancer was not found,and high-risk HPV infection rate was as high as83.33%.There was significant difference between the high-risk HPV infection rate and low-risk HPV infection rate of different patients with cervical lesions(P0.05);there were 30single infection cases in patients with cervicitis/genital warts,accounting for 56.60%;seven cases of multiple infections,accounting for 13.21%;single infection and multiple infection rates of CIN patients were 60.00%,15.38%,respectively.There were 8patients with single infection,2cases with multiple infections in cervical cancer patients,accounting for 66.67%,16.67%respectively.CONCLUSIONThe major type of high-risk HPV persistent or multiple infections was closely related to the cervical cancer.It is necessary to prevent the cervical cancer timely based on the HPV infection subtype test results of patients with cervical lesions.