Screening analysis on pregnant women with Down’s syndrome (Report of 1 000 cases)

Objective To investigate the clinical value of second trimester Down’s syndrome screening.Methods The level of serum AFP and free-β-hCG of 1 000 pregnant women(14-21 weeks)were detected by time-distinguished fluorescence immunoassay.The value of serum markers combined with the maternal age,body weight,gestational age,race,past medical history and other factors were taken into account to conduct a comprehensive analysis by the screening software.Results In 1 000 cases of pregnant women,22 cases were considered as high risk of Down’s syndrome,thereby the positive rate was 2.2%.All the positive cases of Down’s syndrome screening received amniocentesis,1 case of which was Down’s syndrome,accounting for 4.55%;4 cases were 18-trisomy,accounting for 0.4% of all the cases;2 cases were of high risk of neural tube defect,accounting for 0.2% of all the cases;12 cases of the pregnant women aged 35 year-old were of high risk,accounting for 1.2% of all the cases.Conclusion Maternal serum AFP and free-β-hCG level in second trimester are effective indicators for predicting abnormal fetal and adverse pregnancy outcomes.It’s an effective way to reduce the rate of congenital defect.Combining the detection of maternal serum AFP and free-β-HCG level with amniotic fluid or umbilical cord blood detection and B-ultrasonic examination may improve the effective rate of prenatal screening.Therefore,in order to give a good prenatal care and improve the quality of newborn babies it is necessary to popularize prenatal detection and make more pregnant women realize the importance of prenatal screening.