Analysis on prenatal serological screening results of 10263 women at second trimester of pregnancy in Foshan area

Objective:To explore the clinical application value of maternal serum markers in screening of birth defects at second trimester of pregnancy.Methods:10 263 pregnant women at 14~22 gestational weeks who visited the hospital from January 2006 to December 2009 were selected,immunochemistry luminescence method was used to detect the levels of maternal serum markers including alpha-fetoprotein(AFP),free beta-human chorionic gonadotrophin(Fβ-HCG) and unconjugated estriol(uE3).Results:Among 10 263 pregnant women,718 pregnant women were found with high risk of Down's syndrome,accounting for 7.0%;51 pregnant women were found with high risk of neural tube defect,accounting for 0.5%;7 cases,2 cases,16 cases and 4 cases were definitely diagnosed as Down's syndrome,trisomy 18,other chromosome abnormalities and neural tube defect,respectively;among the high risk pregnant women who did not receive prenatal diagnosis,one case were found with Down's syndrome,2 cases were found with Down's syndrome during follow-up among the low risk pregnant women.Conclusion:Triple biomarkers of maternal serum at second trimester of pregnancy are effective in noninvasive prenatal screening in order to reduce the incidences of birth defects,combining with other prenatal screening techniques may improve the clinical efficacy of prenatal screening.