Prenatal Screening in Mid-Pregnancy Women:Analysis of 1200 Cases

Objective:To assess the value of triple test with three maternal serum markers:α-fetoprotein(AFP),free-β-human chorionic gonadotrophin(free-β-hCG)and unconjugated estriol(uE3) in the second trimester prenatal screening.Methods:Prenatal serum screening were offered to the 14～22 weeks pregnant women by measuring the serum AFP,free-βhCG and uE3 with ELISA and calculating the risk by special software.If the risk is high,the pregnant women were advised to do prenatal diagnosis.Results:Within 1 200 cases of women,the cases in high risk are 73,including 65 cases in Down's syndrom,5 cases in 18-trisomy and 3 cases in neural tube defect.The false positive rate were 6.08%,and the detect rate were 100%(2/2).1 case was confirmed the Down's syndrome by cytogenetics analysis,another 1 case was diagnosed the neural tube defect via ultrasonography.adverse obstetric outcome between high risk group and the low risk group were 17.1% and 1.32%,the difference was significant(P 0.01).Conclusion:The prenatal screening with maternal serum markers:AFP,Free-βhCG and uE3 is an effective and safe screening strategy,and the high risk result is helpful in obstetric outcome.