Necessity research of Down syndrome screening in maternal prenatal diagnosis

Objective To study the important significance of Down syndrome screening in the maternal prenatal diagnosis.Methods Maternal serum AFP,β-HCG and free estriol(UE3) were detected in the mid-pregnancy(14-20 weeks) for screening Down syndrome.Then the screened high-risk women were diagnosed by amniocentesis,fluorescent in situ hybridazation and amniotic fluid culture for chromosome analysis.Results A total of 3 654 singleton pregnant women were included in the study.Among them,192 cases were more than 35 years old and accounted for 5.2% of total screening number.By the primary screening,103 cases were found at high risk of Down syndrome with the screening positive rate of 2.81%.Among pregnant women with amniotic fluid prenatal diagnosis,3 cases were found to have abnormal chromosomes and accounted for 2.91%.Among 383 pregnant women without receiving Down syndrome prenatal screening,only 1 cases of Down syndrome was found.Comparing the two groups showed statistical difference(P0.05).Conclusion The serological screening increases the abnormality detection rate in maternal prenatal screening diagnosis.The screening system has important reference value in judging the abnormal pregnant outcomes.