Application of amniotic cell karyotyping in the prenatal diagnosis

Objective:The aim of this study was to make prenatal diagnosis for the fetus with certain chromosomal diseases reduce birth defects.Methods: Amniotic cell gotten by amniocentesis were cultured and karyotyped.Results:Cases were cultured successfully in 477 cases.The successful rate was 99.16%.Among 25 cases with chromosomal abnormality cases in 481.Cases who were karyotyped,which take 5.19 % of the total cases.Among 25 cases with karyotype disorder,4 cases were autosomal chromosomal abnormalities,1 cases were sex chromosomal abnormalities,1 cases were mosaics,3 cases were balanced translocations and 16 cases were other chromosomal abnormalities.Conclusion:Amniocentesis and kargotyping not only can check out fetal chromosome abnormality in time,but also can provide the scientific basis for whether to continue the pregnancy.