Clinical analysis on prenatal diagnosis of amniocentesis in 818 cases

Objective:To analyze the chromosomal karyotypes of amniotic fluid cells,explore the characteristics of fetal chromosomal abnormality and clinical high risk factors,in order to increase the detection rate of abnormal chromosomal karyotypes.Methods:818 pregnant women of 16～23 gestational weeks were selected,then amniotic cell culture,slice production and G band staining technique were conducted for chromosomal analysis.Results:46 cases with abnormal chromosomal karyotypes were found,including 21 cases with chromosomal number abnormality and 25 cases with chromosomal structural abnormality; the detection rates of chromosomal abnormality in cases with abnormal ultrasound results and one of the couple with chromosomal abnormality were significantly higher than those with 21-trisome and advanced age (P0.05),there was no significant difference in detection rate of chromosomal abnormality between cases with 21-trisome and pregnancy of advanced age (P0.05). Conclusion:It is necessary for the cases with high risk of serological screening and advanced age to receive prenatal diagnosis,and for the cases with abnormal fetuses indicated by ultrasound and one of the couple with chromosomal abnormality,fetal chromosomal abnormality should be concerned.