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EXPRESSION AND CLINICAL SIGNIFICANCE OF 5-LIPOXYGENASE IN HUMAN BREAST CANCER

Peijian Ding

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Abstract

Objective:To investigate the expression and clinical significance of 5-lipoxygenase(5-LOX) in breast cancer.Methods:SP immunohistochemical staining was used to detect the expression of 5-LOX protein in 74 cases breast cancer,24 cases para-carcinoma tissue and 18 cases normal breast tissue;and the relationship between 5-LOX expression and clinic pathological features of breast cancer was analyzed.Results:The positive expression rate of 5-LOX in breast cancer was obviously higher than para-carcinoma tissue and normal breast tissue(P0.01) . 5-LOX expression had positive correlation with tumor size,histological grade,TNM stage and lymph node metastasis(P0.05);but has no relations with age,ER and PR.Conclusions:5-LOX may play an important role in development and metastasis of human breast cancer and may be acted as an independent index to judge the prognosis of breast cancer.

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What this paper is about

Objective:To investigate the expression and clinical significance of 5-lipoxygenase(5-LOX) in breast cancer.Methods:SP immunohistochemical staining was used to detect the expression of 5-LOX protein in 74 cases breast cancer,24 cases para-carcinoma tissue and 18 cases normal breast tissue;and the relationship between 5-LOX expression and clinic pathological features of breast cancer was analyzed.Results:The positive expression rate of 5-LOX in breast cancer was obviously higher than para-carcinoma tissue and normal breast tissue(P0.01) . 5-LOX expression had positive correlation with tumor size,histological grade,TNM stage and lymph node metastasis(P0.05);but has no relations with age,ER and PR.Conclusions:5-LOX may play an important role in development and metastasis of human breast cancer and may be acted as an independent index to judge the prognosis of breast cancer.

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Available abstract

Objective:To investigate the expression and clinical significance of 5-lipoxygenase(5-LOX) in breast cancer.Methods:SP immunohistochemical staining was used to detect the expression of 5-LOX protein in 74 cases breast cancer,24 cases para-carcinoma tissue and 18 cases normal breast tissue;and the relationship between 5-LOX expression and clinic pathological features of breast cancer was analyzed.Results:The positive expression rate of 5-LOX in breast cancer was obviously higher than para-carcinoma tissue and normal breast tissue(P0.01) . 5-LOX expression had positive correlation with tumor size,histological grade,TNM stage and lymph node metastasis(P0.05);but has no relations with age,ER and PR.Conclusions:5-LOX may play an important role in development and metastasis of human breast cancer and may be acted as an independent index to judge the prognosis of breast cancer.

Key concepts: Breast cancer, Immunohistochemistry, Pathological, Breast carcinoma, Medicine, Clinical significance, Stage (stratigraphy), Cancer

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