2013•China Medical EngineeringRequires access

Effects of Ruangan Huajian granul on Expression of VEGF and TGF-β_1 in Liver Fiberosis

Zhao Yanlong

Abstract

【Objective】To investigate the effect of ruangan huajian granul on expression of VEGF and TGF-β1 in liver fiberosis.【Methods】Sixty male adult SD rats were randomLy divided into three groups(n=20 each),control group(A group),acute CCL4hepatic injury model group(B group),ruangan huajian granul(C group).SD rats with exprimental hepatic fibrosis were induced by intraperitoneal injection of l0%CC14,8weeks after modeling,the intervention group by ruangan huajian granuls,The expression of VEGF and TGF-β1 were evaluated after 6weeks.【Results】After treatment,the expression of VEGF and TGF-β1 of B group was higer significantly difference with C group(P0.05).【Conclusion】Ruangan huajian granul may alleviate liver fiberosis in rats,it was possibly through decreasing the expression of VEGF and TGF-β1.

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Key concepts: Medicine, Intraperitoneal injection, Transforming growth factor, Internal medicine, Vascular endothelial growth factor, Endocrinology, VEGF receptors