Effect of Ruangan Huajian granule on liver function and serum TGF-β_1 level in C57 mice with experimental hepatic fibrosis

Objective To study of the effect of Ruangan Huajian Granule on liver function and serum TGF-β1 in C57 mice with experimental hepatic fibrosis.Methods 60 mice were randomly divided into six groups,normal control group,normal Ruangan Huajian Granule group,model control group,model Ruangan Huajian Granule low dose group,model Ruangan Huajian Granule high-dose group and model colchicine group.There were 10 mice in every group.C57 mice with experimental hepatic fibrosis were induced by intraperitoneal injection of 10% CCl4.Ruangan Huajian Granule and colchicine was applied different groups.The levels of serum ALT,AST and TGF-β1 were detected in the six groups.Results ALT,AST and TGF-β1 in model control group were higher than those of normal control group(P 0.05).The levels of serum ALT,AST and TGF-β1 in model Ruangan Huajian Granule low dose group,model Ruangan Huajian Granule high-dose group and model colchicine group were notably lower than those of model control group(P 0.05).The levels of ALT and AST in model Ruangan Huajian Granule high-dose group was lower than those of model colchicine group(P 0.05).Conclusion s Ruangan Huajian Granule can improve liver function and inhibit the production of TGF-β1.It is of definite therapeutic and preventive value for mice with experimental hepatic fibrosis.