2011•Shijie zhongxiyi jiehe zazhiRequires access
Effect of Ruangan Huajian Particles on LEP and PDGF in C57 Rats with Experimental Hepatic Fibrosis
Erhei Dai
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Abstract
Objective To observe the effect of ruangan huajian particles on serum leptin(LEP)and platelet derived growth factor(PDGF)in C57 rats with experimental hepatic fibrosis.Methods 60 C57 rats were randomly divided into six groups,a normal control group,a normal ruangan huajian particles group,a model control group,a ruangan huajian particles low-dose group,a ruangan huajian particles high-dose group and a colchicine group,10 rats in each group.The medication was given according to the methods in reference literatures.The levels of LEP and PDGF were detected in each group.Results The levels of serum LEP and PDGF in low-dose group and high-dose ruangan huajian particles group were significantly lower than those in model control group(P0.05).The level of serum PDGF only in colchicine group was significantly lower than that of model control group(P0.05).Conclusion Ruangan huajian particles can block the occurrence and development of hepatic fibrosis through inhibiting the production of LEP and PDGF.It has a certain preventive and therapeutic effect on experimental hepatic fibrosis.