Expression of platelet membrane glycoproteins CD62P and itssignificance in patients with transient ischemic attack

Objective To study the expression of platelet membrane glycoproteins (MG) CD62P in peripheral blood in patients with transient ischemic attack (TIA) and its clinical significance, and the effects of aspirin on platelet MG. Methods The CD62P expressions of 30 cases of TIA patients were measured with flow cytometry (FCM), including patients (9 cases) with progressing to infarction and non-progressing (21 cases). Whether taking aspirin orally or not, samples were divided into 2 groups (the former 12 cases, the latter 18 cases). And the results between groups and between the patients and healthy volunteers were compared. Results The expression of CD62P in healthy volunteers was lower, the positive rate was (30.17±3.55)% while that of TIA patients was higher, the positive rate was (65.23±21.11)%, among which positive rate of patients progressing to infarction was (68.21±2.42)% and that of non-progressing patients was (60.07±3.46)%. After TIA patients took orally aspirin more than 6 months regularly, the activation rate of platelet was (60.75±2.03)%. Patients without aspirin taken orally had a platelet activation rate of (70.01±3.43)%. Conclusion CD62P is able to reflect the activation level of platelet so as to forecast the onset of TIA and to estimate its evolvement trend; aspirin may play a suppressive effect on CD62P expression.