Research of the Relationship of Aspirin Resistance and Platelet Membrane Glycoprotein CD62p,CD63 and GPIIb IIIa in Patients with Ischemic Stroke

Objective:To investigate the relationship between changes of platelet membrane glycoprotein CD62p,CD63 and GP Ⅱ b / Ⅲ a and aspirin resistance the patients with ischemic stroke.Method:We randomly selected 60 cases with ischemic stroke and 30 cases physical health of the same period from Jan.2009 to Dec.2010 in our hospital.Positive expression rate of CD62p,CD63 and GP Ⅱb/Ⅲ were detervmined by FCM in the crowd.60 cases received aspirin(100mg,qd) for 2 weeks,then given flow cytometry test.They were divided into aspirin resistance group(AR group) and aspirin-sensitive group(AS group),and AR group had 8 cases while AS group had 52 cases.The 30 healthy people were considered as the control group.Determined the positive expression rate of D62p,CD63 and GP Ⅱ b / Ⅲ in the three groups.Results:① The positive expression rate of CD62p,CD63 and GPⅡb / Ⅲ in 60 patients was significantly lower than those of before the treatment,however,it was higher than the control group,there were statistically significant differences between the data(P0.01).② AR group of patients with platelet GP Ⅱ b / Ⅲ a expression was higher than which was in the AS group(P 0.01).Conclusion:GP Ⅱ b / Ⅲ a can be used as the reference of ischemic stroke patients treated with aspirin early.