Clinical trial on the expression of platelet membrane glycoproteins CD61,CD62P and the effect of aspirin among patiens with TIA

Objective To observe expression changes of platelet membrane glycoproteins(MG) CD61、CD62P in peripheral blood of patients with transient ischemic attack(TIA) and its clinical significance, and to research the effects of aspirin on platelet MG. Methods To mensurate CD61、CD62P expression of 20 cases of TIA patients with flowcytometry(FCM) and monoclonal antibody, including group progressing to infarction and non-progressing group. Whether taking aspirin orally or not, samples were divided into 2 groups. And compare the results between groups and compare with those of 18 cases of healthy volunteers. Results Result The expression of CD61、CD62P in healthy volunteers was lower while that of TIA patients was higher P 0 01; To compare positive percentage of patients progressing to infarction , and that of nonprogressing patients P 0 01;After TIA patients took orally aspirin more than 6 months regularly, the activation rate of platelet and that of patients without aspirin taken orally, P 0 01; To compare that of male TIA patients and female, P 0 05.Conclusion Activation of platelet is an important factor to the onset of TIA, and the higher activation is, the easier thrombosis is formed. CD61、CD62P is able to reflect the activation of platelet so as to forecast the onset of TIA and to estimate its evolvement trend; meanwhile, aspirin plays a remarkable suppressive effect on CD61、CD62P expression.