Preparation of curcumin liposomes and its oral pharmacokinetics in rats

Objective To prepare Carbopol coated curcumin liposomes,and investigate its oral pharmacokinetics in rats.Methods After prepared by film dispersion method,curcumin liposomes were coated with carbopol. Then mini-column centrifugation method was adopted to determine the encapsulation efficiency (EE) before and after curcumin liposomes being coated. Drug concentration in rats plasma was detected by high performance lipid chromatography (HPLC) after curcumin liposomes administered to rats.Results The EE of curcumin liposomes decreased slightly after coated. Carbopol coated curcumin liposomes after oral administration in rats showed two-compartment model pharmacokinetic characteristics,and the relative bioavailability F(%) was 281%,which was 2.22 times as the non-coated curcumin liposomes.Conclusion After coated by carbopol,the oral bioavailability of curcumin liposomes can be significantly improved,and the maximum drug concentration also increased.