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2007•Chinese Journal of Natural MedicinesRequires access

Preparation and Quality Evaluation of Curcumin Liposome for Injection

Qiao Lin

Open publisher page 2 citations

Abstract

AIM: To prepare and evaluate the quality of curcumin liposomes ,which were high drug load, high entrapment efficiency and good stability.METHODS: Curcumin liposomes were prepared by thin film-dispersion high pressure homogenization. The shape of liposomes ,particles size,zeta potential and stability were evaluated. Entrapment efficiency and drug loading were determined by centrifugal ultrafiltration. RESULTS: The average diameter and zeta potential of curcumin liposomes were 120.1 nm and -50.5 mV. The entrapment efficiency was (95.45±0.86)% and drug loading was (4.1±0.1)%. The antiumor activity of curcumin liposomes increased 31.5% in H22 cells, and 22.9% in lewis tumor model, as compared to that of curcumin injection.CONCLUSION: The incorporation of curcumin into liposomes can increase the curcumin stability and antitumor activity.

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What this paper is about

AIM: To prepare and evaluate the quality of curcumin liposomes ,which were high drug load, high entrapment efficiency and good stability.METHODS: Curcumin liposomes were prepared by thin film-dispersion high pressure homogenization. The shape of liposomes ,particles size,zeta potential and stability were evaluated. Entrapment efficiency and drug loading were determined by centrifugal ultrafiltration. RESULTS: The average diameter and zeta potential of curcumin liposomes were 120.1 nm and -50.5 mV. The entrapment efficiency was (95.45±0.86)% and drug loading was (4.1±0.1)%. The antiumor activity of curcumin liposomes increased 31.5% in H22 cells, and 22.9% in lewis tumor model, as compared to that of curcumin injection.CONCLUSION: The incorporation of curcumin into liposomes can increase the curcumin stability and antitumor activity.

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Available abstract

AIM: To prepare and evaluate the quality of curcumin liposomes ,which were high drug load, high entrapment efficiency and good stability.METHODS: Curcumin liposomes were prepared by thin film-dispersion high pressure homogenization. The shape of liposomes ,particles size,zeta potential and stability were evaluated. Entrapment efficiency and drug loading were determined by centrifugal ultrafiltration. RESULTS: The average diameter and zeta potential of curcumin liposomes were 120.1 nm and -50.5 mV. The entrapment efficiency was (95.45±0.86)% and drug loading was (4.1±0.1)%. The antiumor activity of curcumin liposomes increased 31.5% in H22 cells, and 22.9% in lewis tumor model, as compared to that of curcumin injection.CONCLUSION: The incorporation of curcumin into liposomes can increase the curcumin stability and antitumor activity.

Key concepts: Curcumin, Liposome, Zeta potential, Chromatography, Chemistry, Homogenization (climate), Entrapment, Materials science

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