Preparation of carbopol modified curcumin liposomes and study adhesion in vitro

Objective To discuss the methods of improving oral bioavailability of the insoluble drugs.Methods Carbopol modified curcumin liposomes were prepared by film dispersion and incubation technique.Physical stability,encapsulation efficiency and relative coated rate of curcumin liposomes were determined before and after coated.The small intestine of rats was applied to study the adhesion of carbopol coated curcumin liposomes in vitro.Results Carbopol coating has a great effect on the stability of liposomes;compared to unmodified liposomes,carbopol modified curcumin liposomes possessed a slight decline encapsulation efficiency;relative coated rate increased with the increase of the concentration of carbopol.At the same concentration,the adhesion rate of carbopol modified liposomes were higher than the ones modified with chitosan in vitro.The non-coated liposomes have almost no adhesion.Conclusions Carbopol modified curcumin liposomes,which meet the requirements of insoluble drug curcumin in the oral administration,will have a very good prospect.