Clinical application of Amiodarone combined with Irbesartan on treatment in paroxysmal atrial fibrillation patients

Aim To observe the effect of Amiodarone combined with Irbesartan treating paroxysmal atrial fibrillation.Method From May 2008 to May 2010,83 paroxysmal atrial fibrillation patients were enrolled and randomly divided into treatment group and control group.The treatmrent group was treated with Amiodarone and Irbesartan,and the control group only with Amiodarone.All the patients had been observed for 12 months.Results The sinus rhythm maintenance rate in treatment group was higher than that in control group and the atrial diameter decreased remarkably in treatment group than in control group(P0.05).Conclusion Irbesartan can inhibit electronic and anatomical remodeling of atrial,reduce the recurrence rate of atrial fibrillation,prevent persistence of atrial fibrillation and maintain the sinus rhythm rate more effectively than Amiodarone only,and it can also inhibit the increase of the left atrial diameter.