2012•Xinxueguan kangfu yixue zazhiRequires access
Maintenance of sinus rhythm by irbesartan combined with amiodarone after cardioversion in patients with paroxysmal atrial fibrillation
Lin Xiao-feng
Open publisher page 0 citations
Abstract
Objective:To study maintenance of sinus rhythm by irbesartan combined with amiodarone after cardioversion in patients with paroxysmal atrial fibrillation(PAF) and its influence on left atrial diameter.Methods:A total of 89 PAF patients were divided into amiodarone treatment group(n=44,only received amiodarone) and combination therapy group(n=45,received amiodarone and irbesartan).All patients were followed up for 12 months.Changes of maintenance rate of sinus rhythm and left atrial diameter before and after treatment were observed and compared between the two groups.Results:Compared with amiodarone group after 12 months,there was significant increase in maintenance rate of sinus rhythm(64.3% vs.81.4%) and significant decrease in left atrial diameter [(40.12±10.6) mm vs.(34.10±10.11) mm] in combination therapy group,P0.05 both.Conclusion:Maintenance of sinus rhythm by irbesartan combined with amiodarone after cardioversion in patients with paroxysmal atrial fibrillation is significantly better than that of single amiodarone treatment,and irbesartan combined with amiodarone significantly inhibits left atrial enlargement without significant adverse reactions.