Comparison of therapeutic effects of continuous subcutaneous Insulin infusion and conventional subcutaneous Insulin injection in treatment of type 2 diabetes

Objective:To compare the clinical effects of continuous subcutaneous Insulin infusion(CSII) and conventional subcutaneous Insulin injection in treatment of type 2 diabetes and diabetic ketoacidosis.Methods: 80 hospitalized patients with type 2 diabetes were divided into treatment group(40 cases) and control group(40 cases) which received insulin pump and subcutaneous injection of Insulin respectively.Blood glucose control time,Insulin dosage,incidence rate of hypoglycemia and days of negative conversion of urine ketone of the two groups were compared.Results: In the treatment and the control group,the days of negative conversion of urine ketone were(2.90±1.41),(4.35±1.24) d respectively,Insulin dosages were(39.84±11.24),(53.21±10.45) U/d respectively,the target blood glucose reaching time were(6.03±2.13),(9.32±4.15) d respectively,the hypoglycemia incidence rates were 5.0% and 20.0% respectively,and the HbA1c levels after treatment for 3 months were(7.02±1.84)% and(7.84±1.92)% respectively,and there were significant differences between them(P0.05 or P0.01).Blood glucose levels in four different periods after treatment of the two groups were compared,the treatment group was obviously lower than that of the control group,and there were significant differences between them(P0.05 or P0.01).Conclusion: Compared with conventional subcutaneous insulin injection,CSII has obviously reduced the time to reach target blood glucose,the negative reversion time of urine ketone and the incidence rate of hyperglycemia,which is safe,effective and stable.